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Gastroenterology: Morning and Noon Conference

Morning and Noon Conference

February 2020

Non-alcoholic fatty liver disease (NAFLD) IN 2020, Rotonya M Carr, MD 2/4/20

Risk of severe liver disease in nonalcoholic fatty liver disease with normal aminotransferase levels: a role for insulin resistance and diabetes.

https://aasldpubs.onlinelibrary.wiley.com/doi/full/10.1002/hep.22429

Predictive value of ALT levels for non-alcoholic steatohepatitis (NASH) and advanced fibrosis in non-alcoholic fatty liver disease (NAFLD).

https://onlinelibrary.wiley.com/doi/full/10.1111/liv.12226

Perilipin Staining Distinguishes Between Steatosis and Nonalcoholic Steatohepatitis in Adults and Children.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5161563/

Design and validation of a histological scoring system for nonalcoholic fatty liver disease.

https://aasldpubs.onlinelibrary.wiley.com/doi/full/10.1002/hep.20701

Fibrosis progression in nonalcoholic fatty liver vs nonalcoholic steatohepatitis: a systematic review and meta-analysis of paired-biopsy studies.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4208976/

Evidence of NAFLD progression from steatosis to fibrosing-steatohepatitis using paired biopsies: implications for prognosis and clinical management.

https://www.sciencedirect.com/science/article/pii/S0168827814008836?via%3Dihub

Nonalcoholic Fatty Liver Disease: Pathophysiology and Management.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127277/

Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity.

https://aasldpubs.onlinelibrary.wiley.com/doi/full/10.1002/hep.20466

Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy: a prospective study.

https://www.clinicalkey.com/#!/content/playContent/1-s2.0-S0016508510014162?returnurl=null&referrer=null

Prevalence and associated factors of non-alcoholic fatty liver disease in patients with type-2 diabetes mellitus.

https://onlinelibrary.wiley.com/doi/epdf/10.1111/j.1478-3231.2008.01718.x

Clinical Model for NASH and Advanced Fibrosis in Adult Patients With Diabetes and NAFLD: Guidelines for Referral in NAFLD.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477334/

Nonalcoholic steatohepatitis is the most rapidly growing indication for liver transplantation in patients with hepatocellular carcinoma in the U.S.

https://aasldpubs.onlinelibrary.wiley.com/doi/full/10.1002/hep.26986

Self-reported hypertension treatment beliefs and practices of primary care physicians in a managed care organization.

https://academic.oup.com/ajh/article/18/4/566/116312

Nonalcoholic fatty liver disease is underrecognized in the primary care setting.

https://insights.ovid.com/pubmed?pmid=24890441

Long-term follow-up of patients with nonalcoholic fatty liver.

https://www.clinicalkey.com/#!/content/playContent/1-s2.0-S1542356508011191?returnurl=null&referrer=null

Increased overall mortality and liver-related mortality in non-alcoholic fatty liver disease.

https://www.clinicalkey.com/#!/content/playContent/1-s2.0-S0168827808004236?returnurl=null&referrer=null

The Hierarchical Model of NAFLD: Prognostic Significance of Histologic Features in NASH.

https://www.clinicalkey.com/#!/content/playContent/1-s2.0-S0016508515008756?returnurl=null&referrer=null

Liver Fibrosis, but No Other Histologic Features, Is Associated With Long-term Outcomes of Patients With Nonalcoholic Fatty Liver Disease.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516664/

Genetic contributions to NAFLD: leveraging shared genetics to uncover systems biology.

https://www.nature.com/articles/s41575-019-0212-0

Management of nonalcoholic fatty liver disease: a 60-year-old man with probable nonalcoholic fatty liver disease: weight reduction, liver biopsy, or both?

https://jamanetwork.com/journals/jama/fullarticle/1206650

The effects of fatty deposits on the accuracy of the Fibroscan® liver transient elastography ultrasound system.

https://www.ncbi.nlm.nih.gov/pubmed/22643042

Liver biopsy.

https://www.ncbi.nlm.nih.gov/pubmed/15307851

The utility of radiological imaging in nonalcoholic fatty liver disease.

https://www.sciencedirect.com/science/article/pii/S001650850200166X?via%3Dihub

Weight Loss Through Lifestyle Modification Significantly Reduces Features of Nonalcoholic Steatohepatitis.

https://www.clinicalkey.com/#!/content/playContent/1-s2.0-S0016508515004965?returnurl=null&referrer=null

Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928471/

Continuation of metformin use after a diagnosis of cirrhosis significantly improves survival of patients with diabetes.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4218882/

Statins and hepatic steatosis: perspectives from the Dallas Heart Study.

https://aasldpubs.onlinelibrary.wiley.com/doi/full/10.1002/hep.21248

Efficacy and safety of the farnesoid X receptor agonist obeticholic acid in patients with type 2 diabetes and nonalcoholic fatty liver disease.

https://www.clinicalkey.com/#!/content/playContent/1-s2.0-S0016508513008408?returnurl=null&referrer=null

Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447192/

FXR agonists as therapeutic agents for non-alcoholic fatty liver disease.

https://link.springer.com/article/10.1007%2Fs11883-015-0500-2

Mechanisms of NAFLD development and therapeutic strategies.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6553468/

Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): a multicentre, double-blind, randomised, placebo-controlled phase 2 study.

https://www.clinicalkey.com/#!/content/playContent/1-s2.0-S014067361500803X?returnurl=null&referrer=null

Piloting a multidisciplinary clinic for the management of non-alcoholic fatty liver disease: initial 5-year experience.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5369842/

Modeling NAFLD disease burden in China, France, Germany, Italy, Japan, Spain, United Kingdom, and United States for the period 2016-2030.

https://www.sciencedirect.com/science/article/pii/S0168827818321214?via%3Dihub

Influence of non-alcoholic fatty liver disease on the development of diabetes mellitus.

https://onlinelibrary.wiley.com/doi/full/10.1111/j.1440-1746.2012.07264.x

Meta-analysis: natural history of non-alcoholic fatty liver disease (NAFLD) and diagnostic accuracy of non-invasive tests for liver disease severity.

https://www.ncbi.nlm.nih.gov/pubmed/21039302

Non-alcoholic fatty liver disease and risk of incident cardiovascular disease: A meta-analysis.

https://www.clinicalkey.com/#!/content/playContent/1-s2.0-S0168827816301994?returnurl=null&referrer=null

Awareness of nonalcoholic steatohepatitis and associated practice patterns of primary care physicians and specialists.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788895/

Bariatric Surgery Reduces Features of Nonalcoholic Steatohepatitis in Morbidly Obese Patients.

https://www.sciencedirect.com/science/article/pii/S0016508515005703?via%3Dihub

Risk for development of severe liver disease in lean patients with nonalcoholic fatty liver disease: A long-term follow-up study.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5776871/

A Randomised Controlled Trial on the Effectiveness and Adherence of Modified Alternate-day Calorie Restriction in Improving Activity of Non-Alcoholic Fatty Liver Disease.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6677794/

Glyphosate Excretion is Associated With Steatohepatitis and Advanced Liver Fibrosis in Patients With Fatty Liver Disease.

https://www.clinicalkey.com/#!/content/playContent/1-s2.0-S1542356519303611?returnurl=null&referrer=null

Association of nonalcoholic fatty liver disease (NAFLD) with hepatocellular carcinoma (HCC) in the United States from 2004 to 2009.

https://aasldpubs.onlinelibrary.wiley.com/doi/full/10.1002/hep.2812

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