Thrombotic microangiopathic anemia in patients with sickle cell disease and its variants during a vaso-occlusive crisis.Res Pract Thromb Haemost . 2025 Mar :9(2):102734. doi: 10.1016/j.rpth.2025.102734. eCollection 2025 Feb.
This review highlights that TMA including aTTP can arise in patients with SCD and its variants during a VOC, with symptoms overlapping with other differentials complicating the diagnosis. When a patient in VOC is strongly suspected to have TMA including aTTP, in the absence of clear alternative explanation, clinicians should initiate early PLEX irrespective of presence or absence of schistocytes. Similarly, when differentiating between FES and aTTP is challenging, early initiation of PLEX should be the first choice of treatment, as it may be effective in both conditions [23]. This study is constrained by the disease’s rarity, reliance on case reports, and potential diagnostic overlap with other conditions.
PMID 40242194 | DOI: 10.1016/j.rpth.2025.102734
